老鼠發情週期偵測器

Mouse Estrus Detector

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Mouse Estrus Detector
Mouse Estrus Detector MEDPro™

ELMI的老鼠發情檢測器使用一種簡單而巧妙的方法來告訴何時雌性老鼠準備繁殖（稱為發情期）。為什麼需要這個裝置：雌性老鼠在其生殖週期中經歷不同的階段，知道她們何時處於發情期對於繁殖、實驗以及最小化研究所需的動物數量都是重要的。目前的方法，如在顯微鏡下檢查陰道細胞，對老鼠來說既緩慢又有壓力。這個裝置的工作原理：微型探頭：這個裝置有一個小而光滑的探頭，輕輕插入老鼠的陰道。電阻測量：探頭發送一個微弱的電信號，這個信號太弱以致於不會對老鼠造成傷害，但足夠強大以測量陰道內組織的電阻。電阻的變化取決於老鼠在生殖週期中的哪一個階段。發情檢測：在發情期間，該組織的電阻相較其他階段較高。當裝置測得的電阻高於某個閾值（約6 kΩ）時，會告訴研究人員老鼠處於發情期。為什麼這個裝置更好：快速無痛：過程僅需一秒鐘，不會對老鼠造成疼痛，也不會產生壓力。準確：這個裝置比舊有的方法更可靠更快速，如目視檢查或血液和尿液的實驗室測試。實際好處：它允許科學家更好地把握繁殖或實驗的時機，這有助於減少所需的動物數量。此外，它符合3R原則：替代、減少和改善在研究中使用動物的方式。總之，MEDPro™是一種快速、準確且友善動物的工具，利用電信號檢測老鼠何時準備繁殖，從而改善研究實踐和動物福利。

Technical Data

The Mouse Estrus Detector (MedPro™)

Uses a simple yet clever method to tell when a female mouse is ready to reproduce (a phase called estrus).

Why the device is needed:

• Female mice go through different phases in their reproductive cycle, and knowing when they are in the estrus phase is important for breeding, experiments, and minimising the number of animals needed for research.
• Current methods, like checking vaginal cells under a microscope, are slow and stressful for the mice.

How the device works:

• Tiny Probe: The device has a small, smooth probe that is gently inserted into the mouse’s vagina.
• Electric Resistance Measurement: The probe sends a tiny electric signal that’s too weak to harm the mouse but strong enough to measure the resistance of the tissue inside the vagina. The resistance changes depending on what stage of the reproductive cycle the mouse is in.
• Estrus Detection: During estrus, the tissue has higher resistance compared to other phases. When the device measures resistance higher than a certain threshold (about 6 kΩ), it tells the researchers that the mouse is in estrus.

Why it’s better:

• Quick & Painless: The process takes only a second, doesn’t hurt the mouse, and doesn’t cause stress.
• Accurate: The device is more reliable and faster than older methods like visual checks or lab tests of blood and urine.

Practical Benefits:

• It allows scientists to better time breeding or experiments, which helps reduce the number of animals needed. Plus, it aligns with the 3Rs principle: Replacement, Reduction, and Refinement of animal use in research.

In summary, the MedPro™ is a fast, accurate, and animal-friendly tool that uses electrical signals to detect when a mouse is ready to breed, improving research practices and animal welfare.

Articles and publications:

1. International Journal for Molecular Science
   Advancing 3Rs: The Mouse Estrus Detector (MED) as a Low-Stress, Painless, and Efficient Tool for Estrus Determination in Mice
2. Laboratory Animals for Science
   Instrumental Method For Determining The Estrous Cycle Stages In Small Laboratory Rodents